Our skilled, experienced staff measure behavioral endpoints quickly and accurately to evaluate analgesic compounds and validate novel approaches. Our team is capable of dosing test substances using a variety of standard routes including intravenous, intraperitoneal, subcutaneous, intramuscular, epidural, and oral. We are also prepared to dose compounds directly to the CNS by intrathecal or intraventricular catheters or pumps.
Each model is validated with reference compounds (e.g., gabapentin, morphine or others, as required by our partners). Careful monitoring and observation ensures that gross motor or behavioral impairment does not confound the interpretation of the behavioral endpoints. Finally, we deliver raw and analyzed data with rigorous statistical analysis for every project. A modular per-arm pricing approach facilitates flexible experimental design to accommodate our clients’ needs.
We work closely with our partners to design and execute flexible pain research programs to facilitate critical decisions. Some examples include:

    Neuropathic Pain
        •  Nerve injury models (SNL, CCI, SCI)
        •  Diabetic polyneuropathy
        •  Chemotherapy-induced peripheral neuropathy

    Chronic Pain            
        •  MIA-induced osteoarthritis pain
        •  CFA-induced joint pain
        •  Rat model of bone cancer pain (MRMT)

    Inflammatory Pain
        •  Formalin test
        •  Complete Freund’s Adjuvant (CFA)
        •  Carrageenan
        •  Capsaicin

    Mechanical Trauma
        •  Plantar incision model of post-surgical pain (Brennan model)

    Acute Pain
        •  Tail flick
        •  Hot plate test

    Visceral Pain and Hypersensitivity
        •  Colorectal Distention Model (CRD) of IBS pain
        •  Interstitial Cystitis (IC) model of urinary bladder pain
        •  Post-operative ileus / gastric motility

    Adverse Events
        •  Rotarod
        •  Irwin test

    Coming soon, we are expanding our capabilities…
        •  PK/PD analysis in pathological state and more
        •   Compound solubility characterization

    Please call for details