Algos researchers contributing papers include; James D. Pomonis, PhD, Susan Gottshall, Cheryl L. Marker, PhD, Patrick J. Little, PhD, Indrani Rajan, PhD and Michael Piesla.
Levin, M.E., Jin, J.G., Ji, R-R., Tong, J., Pomonis, J.D., Lavery, D.J., Miller, S.W., and Chiang, L.W. (2008) Complement activation in the peripheral nervous system following the spinal nerve ligation model of neuropathic pain. Pain 137(1):182-201.
Pomonis, J.D. and Shurman, J.R. (2007) Uses of TENS for pain management. Practical Pain Management 7(6):46-51.
Ilyin, V.I., Pomonis, J.D., Whiteside, G.T., Harrison, J.E., Pearson, M.S., Mark, L., Turchin, P.I., Gottshall, S.L., Carter, R.B., Nguyen, P., Hogenkamp, D.J., Olanrewaju, S., Benjamin, E., and Woodward, R.M. (2006) Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy) phenyl]-pyrimidine-4-carboxamide (PPPA): a potent, broad-spectrum state- dependent sodium channel blocker for treating pain states. The Journal of Pharmacology and Experimental Therapetuics 318(3):1083-93.
Pomonis, J.D., Boulet, J.M., Gottshall, S.L., Phillips, S., Sellers, R., Bunton, T., and Walker, K. (2005) Development and characterization of a rat model of osteoarthritis pain. Pain, 114(3): 339-346.
Whiteside, G.T., Woods, M.E., Pearson, M.S., Pomonis, J.D., Turchin, P.I., and Walker, K. (2005) Ablation of a population of neurons in the dorsal horn of the spinal cord is insufficient to induce sprouting of touch responsive myelinated afferents into the innervation territory of pain sensitive unmyelinated afferents. Medical Hypotheses and Research 2: 275-282.
Whiteside, G.T., Harrison, J.E., Pearson, M.S., Chen, Z., Rotshteyn, Y., Turchin, P.I., Pomonis, J.D., Mark, L., Walker, K. and Brogle, K.C. (2004) DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4,5]dec-3-yl]acetic acid), a novel, systemically-available and peripherally restricted mu opioid agonist with anti-hyperalgesic activity: 2. In vivo pharmacological characterization in the rat. The Journal of Pharmacology and Experimental Therapetuics, 310(2): 793-799.
Peters, C.M., Lindsay, T.H., Pomonis, J.D., Luger, N.M., Ghilardi, J.R., Sevcik, M.A., and Mantyh, P.W. (2004) Endothelin and the tumorigenic component of bone cancer pain. Neuroscience, 126(4): 1043-1052.
Levine, A.S., Olszewski, P.K., Mullett, M.A., Pomonis, J.D., Grace, M.K., Kotz, C.M., and Billington, C.J. (2004) Intra-amygdalar injection of DAMGO: effects on cFos levels in brain sites associated with feeding behavior. Brain Research 1015(1-2):9-14.
Pomonis, J.D., Harrison, J.E., Mark, L., Bristol, D.R., Valenzano, K.J., and Walker, K. (2003) N-(4-tertiarybutylphenyl)-4-(3-chlorophyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflammatory and neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics, 306(1): 387-93.
Egnaczyk, G.F., Pomonis, J.D., Schmidt, J.A., Rogers, S.D., Peters, C., Ghilardi, J.R., Mantyh, P.W., and Maggio, J.E. (2003) Proteomic analysis of the reactive phenotype of astrocytes following endothelin-1 exposure. Proteomics 3(5): 689-698.
Peters, C.M., Rogers, S.D., Pomonis, J.D., Egnaczyk, G.F., Keyser, C.P., Schmidt, J.A., Ghilardi, J.R., Maggio, J.E., and Mantyh, P.W. (2003) Endothelin receptor expression in the normal and injured spinal cord: Potential involvement in injury-induced ischemia and gliosis. Experimental Neurology 180(1): 1-13.
Rogers, S.D., Peters, C.M., Pomonis, J.D., Hagiwara, H., Ghilardi, J.R., and Mantyh, P.W. (2003) Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. Glia 41(2): 180-190.
Luger, N.M., Sabino, M.A., Schwei, M.J., Mach, D.B., Pomonis, J.D., Keyser, C.P., Rathbun, M., Clohisy, D.R., Honore, P., Yaksh, T.L., and Mantyh, P.W. (2002) Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer pain vs. inflammatory pain. Pain 99(3): 397-406.
Mach, D.B., Rogers, S.D., Sabino, M.C., Luger, N.M., Schwei, M.J., Pomonis, J.D., Keyser, C.P., Clohisy, D.R., Adams, D.J., O’Leary, P., and Mantyh, P.W. (2002) Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur. Neuroscience 113(1): 155-166.
Pomonis, J.D., Rogers, S.D., Peters, C.M., Ghilardi, J.R., and Mantyh, P.W. (2001) Expression and localization of endothelin receptors: Implications for the involvement of peripheral glia in nociception. The Journal of Neuroscience 21(3): 999-1006.
Pomonis, J.D., Jewett, D.C., Kotz, C.M., Briggs, J.E., Billington, C.J., and Levine, A.S. (2000) Sucrose consumption increases naloxone-induced cFos immunoreactivity in limbic forebrain. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology) 278(3): R712-R719.
Cleary, J.P., O’Hare, E., Pomonis, J.D., Dittel, P.L., Hofmeister, J.J., Friz,M.M., Billington, C.J., and Levine, A.S. (1999) Discriminative stimulus effects of morphine: central versus peripheral training. Brain Research 847(1): 26-31.
Kotz, C.M., Briggs, J.E., Pomonis, J.D., Grace, M.K., Levine, A.S., and Billington, C.J. (1998) Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein. American Journal of Physiology (Regulatory, Integrative and Comparative Physiology 275(2 Part 2): R478-R484.
O’Hare, E., Cleary, J., Weldon, D.T., Pomonis, J.D., Billington, C.J., and Levine, A.S. (1998) Intrahypothalamic discriminative stimulus effects of neuropeptide Y. Pharmacology, Biochemistry, and Behavior 59(2): 375-378.
Pomonis, J.D., Levine, A.S., and Billington, C.J. (1997) Interaction of the hypothalamic paraventricular nucleus and central nucleus of the amygdala in naloxone blockade of neuropeptide Y-induced feeding revealed by c-fos expression. The Journal of Neuroscience 17(13): 5175-5182.
Pomonis, J.D., Billington, C.J., and Levine, A.S. (1996) Orphanin FQ, agonist of orphan opioid recepotr ORL-1, stimulates feeding in rats. Neuroreport 8(1): 269-371.
BOOK CHAPTERS
Pomonis, J.D. (2006) Rat Models of Osteoarthritis. In: The Encyclopedic Reference of Pain. Schmidt, R.F., and Willis, W.D., eds. Heidelberg, Springer-Verlag.
Valenzano, K.J., Pomonis, J.D., and Walker, K. (2005) TRPV1 antagonists and chronic pain. In: Turning Up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation. Malmberg, A.B. and Bley, K.R., eds. Basel: Birkhauser Verlag.
Ilyin, V.I., Pomonis, J.D., Whiteside, G.T., Harrison, J.E., Pearson, M.S., Mark, L., Turchin, P.I., Gottshall, S., Carter, R.B., Nguyen, P., Hogenkamp, D.J., Olanrewaju, S., Benjamin, E. and Woodward R.M. (2006) Pharmacology of 2-{4-(4-chloro-2-fluorophenoxy) phenyl]-pyrimidine-4-carboxamide: a potent, broad spectrum state-dependent sodium channel blocker for treating pain states. The Journal of Pharmacology and Experimental Therapeutics, 318:1083-1093.
Whiteside, G.T., Gottshall, S.L., Boulet, J.M., Chaffer, S.M., Harrison, J.E., Pearson, M.S., Turchin, P.I., Mark, L., Garrison, A.E. and Valenzano, K.E. (2005) A role for cannabinoid recptors, but not endogenous opioids, in the antinociceptive activity of the CB2-Selective agonist, GW405833. European Journal of Pharmacology, 528:65-72.
Valenzano, K.J., Tafesse L., Lee, G., Harrison J.E., Boulet, J.M., Gottshall, S.L., Mark, L., Pearson M.S., Miller, W., Shan, S., Rabadi, L., Rotshteyn, Y., Chaffer, S.M., Turchin, P.I., Elsmore, D.A., Toth, M., Koetzner, L. and Whiteside G.T. (2005) Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology, 48:658-672.
Tuthill, P.A., Seida, P.R., Barker, W., Cassel, J.A., Belanger, S., DeHaven, R.N., Koblish, M., Gottshall, S.L., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2004)Azepinone as a conformational constraint in the design of kappa receptor agonists. Bioorganic and Medicinal Chemistry Letters 14:5693-5697.
Pomonis, JD, Boulet, JM, Gottshall, SL, Phillips, S, Sellers, R, Bunton, T, and Walker, K. (2005) Development and characterization of a rat model of osteoarthritis pain. Pain, 114(3): 339-346.
Whiteside, G.T., Harrison J., Boulet, J., Mark, L., Pearson, M., Gottshall, S. and Walker K. (2004) Pharmacological characterization of a rat model of incisional pain. British Journal of Phamacology 141:85-91.
Kumar V., Marella M.A., Cortes-Burgos L., Chang A.C., Cassel J.A., Daubert J.D., DeHaven R.N., DeHaven-Hudkins D.L., Gottshall S.L., Mansson E., and Maycock A.L. (2000) Arylacetamides as peripherally restricted kappa opioid receptor agonists. Bioorganic and Medicinal Chemistry Letters. 10:2567-2570.
Liu W.J., Gottshall S.L. and Hansen P.J. (1997) Increased expression of cell surface markers on endometrial γ/δ T-cell receptor+ intraepithelial lymphocytes induced by the local presence of the sheep conceptus. American Journal of Reproductive Immunology 37:199-205.
Davidson J.A., Wright J.D., Archbald L.F., Klapstein E., Gottshall S.L. and Hansen P.J. (1996) Effect of induced pyometra on luteal lifespan and uterine fluid concentrations of prostaglandins and interferons. Theriogenology. 45:459-470.
Gottshall S.L. and Hansen P.J. (1994) Enhancement of mitogen-induced lymphocyte proliferation in sheep. Journal of Veterinary Medicine B 41:541-548.
Gottshall S.L. and Hansen P.J. (1992) Regulation of leucocyte subpopulations in the sheep endometrium by progesterone. Immunology. 76:636-641.
Smith, S.B., Marker, C.L., Perry, C., Liao, G., Sotocinal, S.G., Austin, J.S., Melmed, K., Clark, J.D., Peltz, G., Wickman, K., and Mogil, J.S. (2008) Quantitative trait locus and computational mapping identifies Kcnj9 (GIRK3) as a candidate gene affecting analgesia from multiple drug classes. Pharmacogenetics and Genomics 18(3):231-41.
Marker, C.L., Lujan, R., Colón, J., and Wickman, K. (2006) Distinct populations of spinal cord lamina II interneurons expressing G protein-gated potassium channels. The Journal of Neuroscience 26(47):12251-12259.
Kulik, A., Fukazawa, Y., Guetg, N., Kasugai, Y., Marker, C.L., Rigato, F., Bettler, B., Wickman, K., Frotscher, M., and Shigemoto, R. (2006) Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. The Journal of Neuroscience 26(16):4289-4297.
Marker, C.L., Loh, H.H., Lujan, R., and Wickman, K. (2005) Spinal G protein-gated potassium channels mediate the analgesia evoked by high doses of mu and delta opioid receptor agonists. The Journal of Neuroscience. 25(14): 3551-3559.
Marker, C.L., Stoffel, M., and Wickman, K. (2004) Spinal G protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. The Journal of Neuroscience 24(11):2806-2812.
Bettahi, I., Marker, C.L., Roman, M.I., and Wickman, K. (2002) Contribution of the Kir3.1 subunit to the muscarinic-gated atrial potassium channel IKACh. Journal of Biological Chemistry 277(50):48282-48288.
Marker, C.L., Cintora, S.C., Roman, M.I., Stoffel, M., and Wickman, K. (2002) Hyperalgesia and blunted morphine analgesia in G-protein-gated potassium channel subunit knockout mice. Neuroreport 13(18):2509-2513.
Torrecilla, M., Marker, C.L., Cintora, S.C., Stoffel, M., Williams, J.T., and Wickman, K. (2002) G protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. The Journal of Neuroscience 22(11):4328-4344.
Sellitto, I., Le Bourdonnec, B., Worm, K., Goodman, A., Savolainen, M.A., Chu, G.H., Ajello, C.W., Saeui, C.T., Leister, L.K., Cassel, J.A., DeHaven, R.N., LaBuda, C.J., Koblish, M., Little, P.J., Brogdon, B.L., Smith, S.A. and Dolle, R.E. (2010) Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability. Bioorg Med Chem Lett 20:387-391.
Le Bourdonnec, B., Windh, R.T., Leister, L.K., Zhou, Q.J., Ajello, C.W., Gu, M., Chu, G.H., Tuthill, P.A., Barker, W.M., Koblish, M., Wiant, D.D., Graczyk, T.M., Belanger, S., Cassel, J.A., Feschenko, M.S., Brogdon, B.L., Smith, S.A., Derelanko, M.J., Kutz, S., Little, P.J., DeHaven, R.N., DeHaven-Hudkins, D.L. and Dolle, R.E. (2009) Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4’-piperidine]-4-yl) benzamide (ADL5747). J Med Chem 52:5685-5702.
Goodman, A.J., Ajello, C.W., Worm, K., Le Bourdonnec, B., Savolainen, M., O’Hare, H., Cassel, J.A., Stabley, G.J., DeHaven, R.N., LaBuda, C.J., Koblish, M., Little, P.J., Brogdon, B.L., Smith, S.A. and Dolle, R.E. (2009) CB2 selective sulfamoyl benzamides: optimization of the amide functionality. Bioorg Med Chem Lett 19:309-313.
Le Bourdonnec, B., Windh, R.T., Ajello, C.W., Leister, L.K., Gu, M., Chu, G.H., Tuthill, P.A., Barker, W.M., Koblish, M., Wiant, D.D., Graczyk, T.M., Belanger, S., Cassel, J.A., Feschenko, M.S., Brogdon, B.L., Smith, S.A., Christ, D.D., Derelanko, M.J., Kutz, S., Little, P.J., DeHaven, R.N., DeHaven-Hudkins, D.L. and Dolle, R.E. (2008) Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: Discovery of N,N-diethyl-4 (5-hydroxyspiro-[chromene-2,4’-piperidine]-4-yl) benzamide (ADL5859). J Med Chem 51:5893-5896.
Worm, K., Zhou, Q.J., Saeui, C.T., Green, R.C., Cassel, J.A., Stabley, G.J., DeHaven, R.N., Conway James, N.C., LaBuda, C.J., Koblish, M., Little, P.J. and Dolle, R.E. (2008) Sulfamoyl benzamides as novel CB2 cannabinoid ligands. Bioorg Med Chem Lett 18:2830-2835.
Le Bourdonnec, B., Barker, W.M., Belanger, S., Wiant, D.D., Conway-James, N.C., Cassel, J.A., O’Neill, T.J., Little, P.J., DeHaven, R.N., DeHaven-Hudkins, D.L. and Dolle, R.D. (2008) Novel trans-3,4-dimtehyl-4-(3-hydroxyphenyl) piperidines as mu receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett 18:2006-2012.
DeHaven-Hudkins, D.L., DeHaven, R.N., Little, P.J. and Techner, L.M. (2008) The involvement of the µ-opioid receptor in gastrointestinal pathophysiology: Therapeutic opportunities for antagonism at this receptor. Pharmacol Ther 117:162-187.
Chu, G.H., Gu, M., Cassel, J.A., Belanger, S., Grazyck, T.M., DeHaven, R.N., Conway-James, N.C., Koblish, M., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2007) Novel malonamide derivatives as potent kappa opioid receptor agonists. Bioorg Med Chem Lett 17:1951-1955.
LaBuda, C.J., Koblish, M., Tuthill, P., Dolle, R.E. and Little, P.J. (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur J Pain 10:505-512.
Chu, G.H., Gu, M., Cassel, J.A., Belanger, S., Stabley, G.J., DeHaven, R.N., Conway-James, N., Koblish, M., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2006) Novel phenylamino acetamide derivatives as potent and selective kappa opioid receptor agonists. Bioorg Med Chem Lett 16:645-648.
Chu, G.H., Gu, M., Cassel, J.A., Belanger, S., Graczyk, T.M., DeHaven, R.N., Conway-James, N., Koblish, M., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2005) Potent and selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints. Bioorg Med Chem Lett 15:5114-5119.
LaBuda, C.J., Koblish, M. and Little, P.J. (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol 527:172-174.
LaBuda, C.J. and Little, P.J. (2005) Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J Neurosci Methods 144:175-181.
Kumar, V., Guo, D., Cassel, J.A., Daubert, J.D., DeHaven, R.N., DeHaven-Hudkins, D.L., Gauntner, E.K., Gottshall, S.L., Greiner, S.L., Koblish, M., Little, P.J., Mansson, E. and Maycock, A.L. (2005) Synthesis and evaluation of novel peripherally restricted κ-opioid receptor agonists. Bioorg Med Chem Lett 15:1091-1095.
Tuthill, P.A., Seida, P.R., Barker, W., Cassel, J.A., Belanger, S., DeHaven, R.N., Koblish, M., Gottshall, S.L., Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. (2004) Azepinone as a conformational constraint in the design of κ-opioid receptor agonists. Bioorg Med Chem Lett 14:5693-5697.
Greenwood-Van Meerveld, B., Gardner, C.J., Little, P.J., Hicks, G.A. and DeHaven-Hudkins, D.L. (2004) Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil 16 (Suppl 2):46-53.
Bowman, B.P., Vaughn, S.R., Walker, Q.D., Davis, S.L., Little, P.J., Scheffler, N.M., Thomas, B.F. and Kuhn, C.M. (1999) Effect of sex and gonadectomy on cocaine metabolism in the rat. J Pharmacol Exp Ther 290:1316-1323.
Swartzwelder, H.S., Richardson, R.C., Markwiese-Foerch, B., Wilson, W.A. and Little, P.J. (1998) Developmental differences in the acquisition of tolerance to ethanol. Alcohol 15:311-314.
Hepburn, M.J., Little, P.J., Gringas, J. and Kuhn, C.M. (1997) Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats. J Pharmacol Exp Ther 281:1350-1356.
Little, P.J., Kuhn, C.M., Wilson, W.A. and Swartzwelder, H.S. (1996) Differential effects of ethanol in adolescent and adult rats. Alcoholism: Clin Exp Res 20:1346-1351.
Little, P.J., Price, R.R., Hinton, R.K. and Kuhn, C.M. (1996) Role of noradrenergic hyperactivity in neonatal opiate abstinence. Drug and Alcohol Dep 41:47-54.
Little, P.J. and Kuhn, C.M. (1995) Ontogenetic studies of tolerance development: Effect of chronic morphine on the hypothalamic-pituitary-adrenal axis. Psychopharmacology 122:78-84.
Windh, R.T., Little, P.J. and Kuhn, C.M. (1995) The ontogeny of µ opiate tolerance and dependence in the rat: Antinociceptive and biochemical studies. J Pharmacol Exp Ther 273:1361-1374.
Little, P.J., Adams, M.L. and Cicero, T.J. (1992) Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the developing male rat. J Pharmacol Exp Ther 263:1056-1061.
Blackford, S.P., Little, P.J. and Kuhn, C.M. (1992) Mu and kappa opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. Endocrinology 131:2891-2897.
Adams, M.L., Little, P.J., Bell, B. and Cicero, T.J. (1991) Alcohol affects rat testicular insterstitial fluid volume and testicular secretion of testosterone and beta-endorphin. J Pharmacol Exp Ther 258:1008-1014.
Little, P.J. and Martin, B.R. (1991) The effects of delta-9-tetrahydrocannabinol and other cannabinoids on cAMP accumulation in synaptosomes. Life Sci 48:1133-1141.
Martin, B.R., Compton, D.R., Thomas, B.F., Prescott, W.R., Little, P.J., Razdan, R.K., Johnson, M.R., Melvin, L.S., Mechoulam, R. and Ward, S.J. (1991) Behavioral, biochemical and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Beh 40:471-478.
Compton, D.R., Little, P.J., Martin, B.R., Gilman, J.W., Saha, J.K., Jorapur, V.S., Sard, H. and Razdan, R.K. (1990) Synthesis and pharmacological evaluation of amino-, azido- and nitrogen mustard analogues of cannabidiol and delta-8-tetrahydrocannabinol. J Med Chem 33:1437-1443.
Compton, D.R., Little, P.J., Martin, B.R., Saha, J.K., Gilman, J., Sard, H. and Razdan, R.K. (1989) Synthesis and pharmacological evaluation of mercapto and thioacetyl analogues of cannabidiol and delta-8-tetrahydrocannabinol. Eur J Med Chem 24:293-298.
Little, P.J., Compton, D.R., Mechoulam, R. and Martin, B.R. (1988) Stereochemical effects of 11-OH-delta-8-THC-Dimethylheptyl in mice and dogs. Pharmacol Biochem Beh 32:661-666.
Little, P.J., Compton, D.R., Johnson, M.R., Melvin, L.S. and Martin, B.R. (1988) Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. J Pharmacol Exp Ther 247:1046-1051.
Little, P.J. Scimeca, J.A. and Martin, B.R. (1988) Distribution of 3H-diisopropylfluorophosphate, 3H-soman and 3H-sarin and their metabolites in mouse brain. Drug Metab Disp 16:515-520.
Little, P.J., Kaplan, N.C. and Martin, B.R. (1987) Pharmacological profile of delta-9-THC carbamate. Alcohol Drug Res 7:517-523.
Glennon, R.A., Little, P.J., Rosecrans, J.A. and Yousif, M. (1987) The effect of MDMA (”Ecstasy”) and its optical isomers on schedule-controlled responding in mice. Pharmacol Biochem Beh 26:425-426.
Martin, B.R., Compton, D.R., Little, P.J., Martin, T.J. and Beardsley, P.M. (1986) Pharmacological evaluation of agonistic and antagonistic activity of cannabinoids. Structure-Activity relationships of the cannabinoids. NIDA Res Mono 79:108-122.
Little, P.J., Reynolds, M.R., Bowman, E.R. and Martin, B.R. (1986) Tissue disposition of [3H]sarin and its metabolites in mice. Toxicol Appl Pharmacol 83:412-419.
Reynolds, M.R., Little, P.J., Thomas, B.F., Bagley, R.B. and Martin, B.R. (1985) Relationship
between the biodisposition of 3H-soman and its pharmacological effects in mice. Toxicol Appl Pharmacol 80:409-420.
Scimeca, J.A., Little, P.J. and Martin, B.R. (1985) Relationship between the pharmacological effects and biodisposition of 3H-diisopropylfluorophosphate in mice after inhalation. Toxicol Appl Pharmacol 79:502-510.
BOOK CHAPTERS
Kuhn, C.M. and Little, P.J. (1995) Neuroendocrine effects of cocaine In: Neurobiology of Cocaine: Cellular and Molecular Mechanisms Ed R Hammer, CRC Press, Boca Raton, pp. 49-63.
Kuhn, C.M., Windh, R.T. and Little, P.J. (1991) Effects of perinatal opiate addiction on neurochemical development of the brain In: Development of the CNS: Effects of Alcohol and Opiates Ed M W Miller, Wiley Liss Inc, New York pp. 339-359.
Compton, D.R., Little, P.J. and Martin, B.R. (1988) Cannabinoid behavioral effects: Specific versus non-specific actions In: Marihuana ‘87: Proceedings of the Melbourne Symposium on Cannabis eds G Chesire, P Consroe and R Musty, NCADA Monograph, Australian Government Publishing Service, Canberra, pp. 213-218.
Rajan, I., Read, R., Small, D.L., Perrard, J., and Vogel, P. (2011) An alternative splicing variant in Clcn7-/- mice prevents osteopetrosis but not neural and retinal degeneration. (Veterinary Pathology May 2011 48(3):663-75)
Ye, G-L., Savelieva, K.V., Baker, K.B., Syrewicz, J., Mason, S., Lanthorn, T.H., and Rajan, I. (2009) Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. (poster presented at IBNS Bahamas June 8-13 2009 and at SFN Chicago Oct 2009)
Rajan, I., Savelieva, K.V., Ye, G-L., Wang, C-Y., Malbari, M., Friddle, C., Lanthorn, T., and Zhang, W. (2009) Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development. PLoS One. 2009 Aug 12;4(8):e6612.
Rajan, I., Vogel, P., Savelieva, K.V., Ye, G-L., Zhang, W., Tran, D., Suwanichkul, A., Small, D., and Lanthorn, T. (2008) Vesicular glutamate transporter 3 is critical for auditory function. (Poster presented at SFN 2008 at Washington D.C.).
Savelieva, K.V., Zhao, S., Pogorelov, V.M., Rajan, I., Yang, Q., Cullinan, E., and Lanthorn, T.H. (2008) Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One 2008:3(10):e3301
Savelieva, K.V., Rajan, I., Baker, K.B., Vogel, P., Jarman, W., Allen, M., and Lanthorn, T.H. (2008) Learning and memory impairments in Eph receptor A6 knockout mice. Neuroscience Lett. 2008 Jun 20:438(2): 205-9.
Zhang, W., Rajan, I., Savelieva, K.V., Wang, C-Y., Vogel, P., Kelly, M., Xu, N., Hasson, B., Jarman, W., and Lanthorn, T.H. (2008) Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness. Genes, Brain and Behavior 2008 Jun;7(4):385-92.
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BOOK CHAPTER
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